Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2008 3
2010 2
2011 1
2013 3
2014 3
2015 3
2016 1
2017 3
2018 3
2019 2
2020 1
2021 2
2023 1
2024 0

Text availability

Article attribute

Article type

Publication date

Search Results

26 results

Results by year

Filters applied: . Clear all
Page 1
Hypomorphism of Fto and Rpgrip1l causes obesity in mice.
Stratigopoulos G, Burnett LC, Rausch R, Gill R, Penn DB, Skowronski AA, LeDuc CA, Lanzano AJ, Zhang P, Storm DR, Egli D, Leibel RL. Stratigopoulos G, et al. J Clin Invest. 2016 May 2;126(5):1897-910. doi: 10.1172/JCI85526. Epub 2016 Apr 11. J Clin Invest. 2016. PMID: 27064284 Free PMC article.
In vivo manipulation of CUX1, Fto, and/or Rpgrip1l expression in mice affected adiposity in a manner that was consistent with CUX1 influence on adiposity via remote effects on Fto and Rpgrip1l expression. ...Together, the results of this study indicate …
In vivo manipulation of CUX1, Fto, and/or Rpgrip1l expression in mice affected adiposity in a manner that was consistent with …
Critical Enzymatic Functions of FTO in Obesity and Cancer.
Deng X, Su R, Stanford S, Chen J. Deng X, et al. Front Endocrinol (Lausanne). 2018 Jul 30;9:396. doi: 10.3389/fendo.2018.00396. eCollection 2018. Front Endocrinol (Lausanne). 2018. PMID: 30105001 Free PMC article. Review.
Although some recent studies suggest that the obesity-related SNPs in FTO influence obesity susceptibility likely through altering the expression of the adjacent genes such as IRX3 and RPGRIP1L, rather than FTO itself, a solid link between the SNP risk genoty …
Although some recent studies suggest that the obesity-related SNPs in FTO influence obesity susceptibility likely through altering th …
Obesity and FTO: Changing Focus at a Complex Locus.
Tung YCL, Yeo GSH, O'Rahilly S, Coll AP. Tung YCL, et al. Cell Metab. 2014 Nov 4;20(5):710-718. doi: 10.1016/j.cmet.2014.09.010. Epub 2014 Oct 23. Cell Metab. 2014. PMID: 25448700 Free article. Review.
Murine models of perturbed Fto expression have shown effects on body weight and composition. However, a clear understanding of the link between FTO intronic variants and FTO activity has remained elusive. Two recent reports now indicate that obesity-associate …
Murine models of perturbed Fto expression have shown effects on body weight and composition. However, a clear understanding of the li …
The role of Rpgrip1l, a component of the primary cilium, in adipocyte development and function.
Carli JFM, LeDuc CA, Zhang Y, Stratigopoulos G, Leibel RL. Carli JFM, et al. FASEB J. 2018 Jul;32(7):3946-3956. doi: 10.1096/fj.201701216R. Epub 2018 Feb 21. FASEB J. 2018. PMID: 29466054 Free PMC article.
These risk alleles are associated with decreased expression of both FTO and neighboring RPGRIP1L (retinitis pigmentosa GTPase regulator-interacting protein 1 like). ...We propose that decreased RPGRIP1L expression in preadipocytes in humans who segregate for …
These risk alleles are associated with decreased expression of both FTO and neighboring RPGRIP1L (retinitis pigmentosa GTPase …
The 'Fat Mass and Obesity Related' (FTO) gene: Mechanisms of Impact on Obesity and Energy Balance.
Speakman JR. Speakman JR. Curr Obes Rep. 2015 Mar;4(1):73-91. doi: 10.1007/s13679-015-0143-1. Curr Obes Rep. 2015. PMID: 26627093 Review.
This review summarises what has been later discovered about the biology of FTO drawing together information from both human and animal studies. ...It has been recently suggested that although the obesity related SNPs reside in the first intron of FTO, they may not o …
This review summarises what has been later discovered about the biology of FTO drawing together information from both human and anima …
Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice.
Stratigopoulos G, Martin Carli JF, O'Day DR, Wang L, Leduc CA, Lanzano P, Chung WK, Rosenbaum M, Egli D, Doherty DA, Leibel RL. Stratigopoulos G, et al. Cell Metab. 2014 May 6;19(5):767-79. doi: 10.1016/j.cmet.2014.04.009. Cell Metab. 2014. PMID: 24807221 Free PMC article.
Common polymorphisms in the first intron of FTO are associated with increased body weight in adults. Previous studies have suggested that a CUX1-regulatory element within the implicated FTO region controls expression of FTO and the nearby ciliary gene, RPG …
Common polymorphisms in the first intron of FTO are associated with increased body weight in adults. Previous studies have suggested …
Cilia signaling and obesity.
Engle SE, Bansal R, Antonellis PJ, Berbari NF. Engle SE, et al. Semin Cell Dev Biol. 2021 Feb;110:43-50. doi: 10.1016/j.semcdb.2020.05.006. Epub 2020 May 25. Semin Cell Dev Biol. 2021. PMID: 32466971 Free PMC article. Review.
The role of the FTO (Fat Mass and Obesity Related) locus in regulating body size and composition.
Yeo GS. Yeo GS. Mol Cell Endocrinol. 2014 Nov;397(1-2):34-41. doi: 10.1016/j.mce.2014.09.012. Epub 2014 Sep 16. Mol Cell Endocrinol. 2014. PMID: 25224490 Review.
However, recent data focussing on obesity associated variants within FTO have implicated two neighbouring genes, RPGRIP1L and IRX3, as having a functional link between the SNP and the observed human phenotypes. As with Fto, perturbing the expression of these …
However, recent data focussing on obesity associated variants within FTO have implicated two neighbouring genes, RPGRIP1L and …
Ciliary gene RPGRIP1L is required for hypothalamic arcuate neuron development.
Wang L, De Solis AJ, Goffer Y, Birkenbach KE, Engle SE, Tanis R, Levenson JM, Li X, Rausch R, Purohit M, Lee JY, Tan J, De Rosa MC, Doege CA, Aaron HL, Martins GJ, Brüning JC, Egli D, Costa R, Berbari N, Leibel RL, Stratigopoulos G. Wang L, et al. JCI Insight. 2019 Feb 7;4(3):e123337. doi: 10.1172/jci.insight.123337. JCI Insight. 2019. PMID: 30728336 Free PMC article.
Intronic polymorphisms in the alpha-ketoglutarate-dependent dioxygenase gene (FTO) that are highly associated with increased body weight have been implicated in the transcriptional control of a nearby ciliary gene, retinitis pigmentosa GTPase regulator-interacting protein- …
Intronic polymorphisms in the alpha-ketoglutarate-dependent dioxygenase gene (FTO) that are highly associated with increased body wei …
The composite alliance of FTO locus with obesity-related genetic variants.
Chauhdary Z, Rehman K, Akash MSH. Chauhdary Z, et al. Clin Exp Pharmacol Physiol. 2021 Jul;48(7):954-965. doi: 10.1111/1440-1681.13498. Epub 2021 Apr 8. Clin Exp Pharmacol Physiol. 2021. PMID: 33735452 Review.
Current investigation has also revealed the link of FTO neighbouring genes i.e., RPGRIP1L, IRX3 and IRX5 and epigenetic factors with obesity phenotypes. The motive behind this review is to cite the consequences of FTO on obesity vulnerability....
Current investigation has also revealed the link of FTO neighbouring genes i.e., RPGRIP1L, IRX3 and IRX5 and epigenetic factor …
26 results